Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine versus povidone-iodine in clean-contaminated surgery.
نویسندگان
چکیده
BACKGROUND Surgical-site infection increases morbidity, mortality and financial burden. The preferred topical antiseptic agent (chlorhexidine or povidone-iodine) for preoperative skin cleansing is unclear. METHODS A meta-analysis of clinical trials was conducted to determine whether preoperative antisepsis with chlorhexidine or povidone-iodine reduced surgical-site infection in clean-contaminated surgery. RESULTS The systematic review identified six eligible studies, containing 5031 patients. Chlorhexidine reduced postoperative surgical-site infection compared with povidone-iodine (pooled odds ratio 0.68, 95 per cent confidence interval 0.50 to 0.94; P = 0.019) . CONCLUSION Chlorhexidine should be used preferentially for preoperative antisepsis in clean-contaminated surgery.
منابع مشابه
Systematic Review and Meta-Analysis of Preoperative Antisepsis with Combination Chlorhexidine and Povidone-Iodine.
Importance Effective preoperative antisepsis is recognized to prevent surgical site infection (SSI), although the definitive method is unclear. Many have compared chlorhexidine (CHG) with povidone-iodine (PVI), but there is emerging evidence for combination usage. Objective To conduct a systematic review and meta-analysis to evaluate if combination skin preparation (1) reduces colonization at...
متن کاملChlorhexidine-Alcohol versus Povidone-Iodine for Surgical-Site Antisepsis.
BACKGROUND Since the patient's skin is a major source of pathogens that cause surgical-site infection, optimization of preoperative skin antisepsis may decrease postoperative infections. We hypothesized that preoperative skin cleansing with chlorhexidine-alcohol is more protective against infection than is povidone-iodine. METHODS We randomly assigned adults undergoing clean-contaminated surg...
متن کاملSystematic review and cost analysis comparing use of chlorhexidine with use of iodine for preoperative skin antisepsis to prevent surgical site infection.
OBJECTIVE To compare use of chlorhexidine with use of iodine for preoperative skin antisepsis with respect to effectiveness in preventing surgical site infections (SSIs) and cost. METHODS We searched the Agency for Healthcare Research and Quality website, the Cochrane Library, Medline, and EMBASE up to January 2010 for eligible studies. Included studies were systematic reviews, meta-analyses,...
متن کاملPrevention of Intravascular Central Venous Catheter- Related Infections: 0.5% Concentration of Chlorhexidine Preparation With Alcohol for Skin Preparation and Femoral Vein for Renal Replacement
To the Editor—We read with great interest the article ‘‘Guidelines for the Prevention of Intravascular Catheter-related Infections’’ in the May 2011 issue [1]. We commend the authors for their excellent extensive review of the literature and subsequent guidelines. These guidelines, however, recommend the use of ‘‘.0.5% chlorhexidine preparation with alcohol for skin antisepsis during CVC insert...
متن کاملChlorhexidine and alcohol versus povidone-iodine for antisepsis in gynecological surgery.
BACKGROUND Surgical site infections (SSIs) cause severe morbidity and are associated with tremendous health costs. Skin antisepsis (cleansing) with chlorhexidine and alcohol solutions has demonstrated superiority to povidone-iodine in a variety of surgical interventions. Our objective was to determine if chlorhexidine and alcohol antisepsis protocol reduces the rate of SSIs in elective gynecolo...
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عنوان ژورنال:
- The British journal of surgery
دوره 97 11 شماره
صفحات -
تاریخ انتشار 2010